Tottenham head to the Etihad looking to end a run of three straight defeats.
This London derby sees David Moyes’ Hammers looking to make it five wins on the spin.
Jurgen Klöpp’s men look to extend their perfect home record as they host Fulham at Anfield.
The Blues take on the high-flying Seagulls at Stamford Bridge.
Pep Guardiola’s men look to wrap up top spot in Group G as they host the German side at the Etihad.